A mathematical model of caspase function in apoptosis

@article{Fussenegger2000AMM,
  title={A mathematical model of caspase function in apoptosis},
  author={Martin Fussenegger and James Edwin Bailey and Jeffrey D. Varner},
  journal={Nature Biotechnology},
  year={2000},
  volume={18},
  pages={768-774}
}
Caspases (cysteine-containing aspartate-specific proteases) are at the core of the cell's suicide machinery. These enzymes, once activated, dismantle the cell by selectively cleaving key proteins after aspartate residues. The events culminating in caspase activation are the subject of intense study because of their role in cancer, and neurodegenerative and autoimmune disorders. Here we present a mechanistic mathematical model, formulated on the basis of newly emerging information, describing… 
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