A mathematical model of antitumor chemotherapy II. Optimization oe schedules of periodic administration of phase-specific cytotoxic agents with blocking action

@article{Gelfand2004AMM,
  title={A mathematical model of antitumor chemotherapy II. Optimization oe schedules of periodic administration of phase-specific cytotoxic agents with blocking action},
  author={E. V. Gel'fand and B. F. Dibrov and A. M. Zhabotinskii and Yu. A. Neifakh and Marianna Orlova and M. N. Flerov},
  journal={Pharmaceutical Chemistry Journal},
  year={2004},
  volume={20},
  pages={681-689}
}
Damage to the stem cells of the hematopoietic system or epithelium of the small intestine is known to restrict the use of many antitumor preparations [12]. It has been pointed out repeatedly in the literature [8, 12] that schedules of administration of chemotherapeutic preparations with selectively increased toxicity for tumor cells compared with cells of… CONTINUE READING