A mathematical model for the germinal center morphology and affinity maturation.

@article{MeyerHermann2002AMM,
  title={A mathematical model for the germinal center morphology and affinity maturation.},
  author={Michael Meyer-Hermann},
  journal={Journal of theoretical biology},
  year={2002},
  volume={216 3},
  pages={
          273-300
        }
}
During germinal center reactions, the appearance of two specific zones are observed: the dark and the light zone. Up to now, the origin and function of these zones are poorly understood. In the framework of a stochastic and discrete model, several possible pathways of zone development during germinal center reactions are investigated. The importance of the zones in the germinal center for affinity maturation, i.e. the process of antibody optimization is discussed. 
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In a comparative approach, constraints on typical lymphocyte velocities in GCs are formulated which are characteristic for the different proposed mechanisms.
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It is shown that an intermediate appearance of dark zones in germinal center reactions is advantageous for the process of antibody optimization.
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TLDR
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TLDR
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TLDR
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TLDR
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Recent research employing in vivo imaging that has begun to untangle some of the mysteries ofGerminal centers is reviewed.
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