A mathematical model for human nucleotide excision repair: damage recognition by random order assembly and kinetic proofreading.

@article{Kesseler2007AMM,
  title={A mathematical model for human nucleotide excision repair: damage recognition by random order assembly and kinetic proofreading.},
  author={Kevin J. Kesseler and William K. Kaufmann and Joyce T. Reardon and Timothy C. Elston and Aziz Sancar},
  journal={Journal of theoretical biology},
  year={2007},
  volume={249 2},
  pages={361-75}
}
A mathematical model of human nucleotide excision repair was constructed and validated. The model incorporates cooperative damage recognition by RPA, XPA, and XPC followed by three kinetic proofreading steps by the TFIIH transcription/repair factor. The model yields results consistent with experimental data regarding excision rates of UV photoproducts by the reconstituted human excision nuclease system as well as the excision of oligonucleotides from undamaged DNA. The model predicts the effect… CONTINUE READING

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