A mathematical analysis of SELEX

  title={A mathematical analysis of SELEX},
  author={Howard A. Levine and Marit Nilsen-Hamilton},
  journal={Computational biology and chemistry},
  volume={31 1},
Systematic evolution of ligands by exponential enrichment (SELEX) is a procedure by which a mixture of nucleic acids that vary in sequence can be separated into pure components with the goal of isolating those with specific biochemical activities. The basic idea is to combine the mixture with a specific target molecule and then separate the target-NA complex from the resulting reaction. The target-NA complex is then separated by mechanical means (for example by filtration), the NA is then… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 21 extracted citations

Controlling uncertainty in aptamer selection.

Proceedings of the National Academy of Sciences of the United States of America • 2016
View 3 Excerpts


Publications referenced by this paper.

Similar Papers

Loading similar papers…