A maternal mRNA localized to the vegetal hemisphere in xenopus eggs codes for a growth factor related to TGF-β

  title={A maternal mRNA localized to the vegetal hemisphere in xenopus eggs codes for a growth factor related to TGF-β},
  author={D. Weeks and D. Melton},
  • D. Weeks, D. Melton
  • Published 1987
  • Biology, Medicine
  • Cell
  • We report that Vg1, a maternal mRNA localized to the vegetal hemisphere of frog eggs, encodes a member of the transforming growth factor-beta (TGF-beta) family of proteins. Furthermore, we show that Vg1 mRNA is distributed to presumptive endodermal cells after fertilization. Previous studies had shown that the vegetal end of a frog egg produces a signal that induces the overlying animal pole cells to form mesodermal tissue. More recently it has been shown that fibroblast growth factor (FGF) and… CONTINUE READING
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