A mass spectrometry based method for distinguishing between symmetrically and asymmetrically dimethylated arginine residues.


The arginine methylation of proteins is involved in several important cellular activities, most notably transcriptional control. Arginine dimethylation can take two distinct forms, symmetric and asymmetric, catalyzed by different classes of enzymes. To establish a method for the mass spectrometric identification and characterization of this post… (More)


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