A mass spectrometric approach for characterization of amyloid-β aggregates and identification of their post-translational modifications.


Endogenous amyloid-β (Aβ) oligomeric aggregates have been proposed as toxic agents in Alzheimer's disease (AD). Knowledge of their structures not only may provide insight into the basis of their neurotoxicities but also may reveal new targets for therapeutic drugs and diagnostic tools. However, the low levels of these Aβ oligomers have impeded structural… (More)
DOI: 10.1021/bi300316d


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