A marine natural product inhibitor of kinesin motors.

@article{Sakowicz1998AMN,
  title={A marine natural product inhibitor of kinesin motors.},
  author={R. Sakowicz and M. S. Berdelis and K. Ray and C. L. Blackburn and C. Hopmann and D. Faulkner and L. Goldstein},
  journal={Science},
  year={1998},
  volume={280 5361},
  pages={
          292-5
        }
}
Members of the kinesin superfamily of motor proteins are essential for mitotic and meiotic spindle organization, chromosome segregation, organelle and vesicle transport, and many other processes that require microtubule-based transport. A compound, adociasulfate-2, was isolated from a marine sponge, Haliclona (also known as Adocia) species, that inhibited kinesin activity by targeting its motor domain and mimicking the activity of the microtubule. Thus, the kinesin-microtubule interaction site… Expand
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References

SHOWING 1-10 OF 12 REFERENCES
Microtubule motor complexes moving membranous organelles.
  • M. Sheetz
  • Biology, Medicine
  • Cell structure and function
  • 1996
Direction of microtubule movement is an intrinsic property of the motor domains of kinesin heavy chain and Drosophila ncd protein.
The kinetic cycles of myosin, kinesin, and dynein.
  • D. Hackney
  • Chemistry, Medicine
  • Annual review of physiology
  • 1996
Going mobile: microtubule motors and chromosome segregation.
  • N. Barton, L. Goldstein
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1996
Kinesin ATPase: rate-limiting ADP release.
  • D. Hackney
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1988
...
1
2
...