A marine diatom-derived aldehyde induces apoptosis in copepod and sea urchin embryos.

@article{Romano2003AMD,
  title={A marine diatom-derived aldehyde induces apoptosis in copepod and sea urchin embryos.},
  author={Giovanna Romano and Gian Luigi Russo and Isabella Buttino and Adrianna Ianora and Antonio Miralto},
  journal={The Journal of experimental biology},
  year={2003},
  volume={206 Pt 19},
  pages={3487-94}
}
The diatom-derived aldehyde 2-trans-4-trans-decadienal (DD) was tested as an apoptogenic inducer in both copepod and sea urchin embryos, using terminal-deoxynucleotidyl-transferase-mediated dUTP nick-end labelling (TUNEL), DNA fragmentation profiling (laddering) and an assay for caspase-3 activity. DD induced TUNEL positivity and DNA laddering, but not caspase-like activation, in copepod embryos spawned by females fed for 10-15 days the diatom diet Thalassiosira rotula Meunier (in vivo), or… CONTINUE READING

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