A marine-derived Streptomyces sp. MS449 produces high yield of actinomycin X2 and actinomycin D with potent anti-tuberculosis activity

@article{Chen2012AMS,
  title={A marine-derived Streptomyces sp. MS449 produces high yield of actinomycin X2 and actinomycin D with potent anti-tuberculosis activity},
  author={Caixia Chen and Fuhang Song and Qian Wang and Wael Mostafa Abdel-Mageed and Hui Guo and Chengzhang Fu and Weiyuan Hou and Huanqin Dai and Xueting Liu and Na Yang and Feng Xie and Ke Yu and Ruxian Chen and Lixin Zhang},
  journal={Applied Microbiology and Biotechnology},
  year={2012},
  volume={95},
  pages={919-927}
}
In the course of our screening program for anti-Mycobacterium bovis bacillus Calmette-Guérin (BCG) and anti-Mycobacterium tuberculosis H37Rv (MTB H37Rv) agents from our marine natural product library, a newly isolated actinomycete strain, designated as MS449, was picked out for further investigation. The strain MS449, isolated from a sediment sample… CONTINUE READING