A map of nuclear matrix attachment regions within the breast cancer loss-of-heterozygosity region on human chromosome 16q22.1.

@article{Shaposhnikov2007AMO,
  title={A map of nuclear matrix attachment regions within the breast cancer loss-of-heterozygosity region on human chromosome 16q22.1.},
  author={Sergey A Shaposhnikov and Sergey B. Akopov and I. Chernov and Preben Dybdahl Thomsen and Claus B Joergensen and Andrew R Collins and Eirik Frengen and Lev G. Nikolaev},
  journal={Genomics},
  year={2007},
  volume={89 3},
  pages={354-61}
}
There is abundant evidence that the DNA in eukaryotic cells is organized into loop domains that represent basic structural and functional units of chromatin packaging. To explore the DNA domain organization of the breast cancer loss-of-heterozygosity region on human chromosome 16q22.1, we have identified a significant portion of the scaffold/matrix attachment regions (S/MARs) within this region. Forty independent putative S/MAR elements were assigned within the 16q22.1 locus. More than 90% of… CONTINUE READING