A map of cytoplasmic RNA transcripts from lytic adenovirus type 2, determined by electron microscopy of RNA:DNA hybrids

@article{Chow1977AMO,
  title={A map of cytoplasmic RNA transcripts from lytic adenovirus type 2, determined by electron microscopy of RNA:DNA hybrids},
  author={Louise T. Chow and James M. Roberts and JAMES B. Lewis and Thomas R. Broker},
  journal={Cell},
  year={1977},
  volume={11},
  pages={819-836}
}
Coordinate regulation of two cytoplasmic RNA species transcribed from early region 2 of the adenovirus 2 genome
TLDR
The elevated accumulation rate for E2 cytoplasmic RNA at late times reflected an increase in formation of both major species, suggesting that the two major species encoded by E2 are regulated in a coordinate fashion late in infection.
Quantitative electron microscopy of early adenovirus RNA.
Structure of late adenovirus 2 heterogeneous nuclear RNA.
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References

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Identification of early adenovirus type 2 RNA species transcribed from the left-hand end of the genome
Unique fragments of adenovirus type 2 DNA generated by cleavage with endonuclease R-Eco RI or endonuclease R-Hsu I (Hin dIII) were used to map cytoplasmic viral RNAs transcribed early in productive
Electron microscopy of late adenovirus type 2 mRNA hybridized to double-stranded viral DNA
TLDR
The map positions of late Ad2 mRNA correlated well to published RNA and protein maps, and two locations at which adjacent mRNA's hybridized to different strands were accurately mapped at positions 0.61 and 0.91 of the DNA.
Mapping of adenovirus 2 RNA sequences in lytically infected cells and transformed cell lines.
TLDR
A tentative map of the cytoplasmic RNA sequences has been constructed for viral RNA extracted from cells both early and late during infection, suggesting that RNA processing and selection may play a role in the regulation of viral mRNA production.
Early gene expression of adenovirus type 2: R-loop mapping of mRNA and time course of viral DNA, mRNA, and protein synthesis
TLDR
A refined map of adenovirus gene functions is presented which is based on results documented in this and the accompanying study by Meyer et al. (1977), as well as on data published by other laboratories.
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