A mannose-specific recognition mediates the defasciculation of axons in the leech CNS.

@article{Zipser1991AMR,
  title={A mannose-specific recognition mediates the defasciculation of axons in the leech CNS.},
  author={Birgit Zipser and Robert N Cole},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1991},
  volume={11 11},
  pages={
          3471-80
        }
}
We are studying a mannose-specific recognition mediating the projection of axons in the synaptic neuropil of the embryonic leech CNS. A functional class of neurons, the sensory afferents, can be distinguished by a mannose-containing epitope that is asparagine-linked to a 130 kDa surface protein and is reactive with the monoclonal antibody Lan3-2. Sensory afferents project as a tightly fasciculated bundle through peripheral nerves but, upon arriving in the CNS, defasciculate into the synaptic… CONTINUE READING

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