A mammalian protein targeted by G1-arresting rapamycin–receptor complex

@article{Brown1994AMP,
  title={A mammalian protein targeted by G1-arresting rapamycin–receptor complex},
  author={E. Brown and M. W. Albers and T. B. Shin and K. Ichikawa and C. Keith and William Arbuthnot Sir Lane and S. Schreiber},
  journal={Nature},
  year={1994},
  volume={369},
  pages={756-758}
}
  • E. Brown, M. W. Albers, +4 authors S. Schreiber
  • Published 1994
  • Biology, Medicine
  • Nature
  • THE structurally related natural products rapamycin and FK506 bind to the same intracellular receptor, FKBP12, yet the resulting complexes interfere with distinct signalling pathways1,2. FKBP12–rapamycin inhibits progression through the Gl phase of the cell cycle in osteosarcoma3, liver4, 5 and T cells6, 7 as well as in yeast8 and interferes with mitogenic signalling pathways that are involved in Gl progression9, 10 namely with activation of the protein p70S6k (refs 5,11–13) and cyclin… CONTINUE READING
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    References

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