A mammalian protein targeted by G1-arresting rapamycin–receptor complex

@article{Brown1994AMP,
  title={A mammalian protein targeted by G1-arresting rapamycin–receptor complex},
  author={E. Brown and M. W. Albers and T. B. Shin and K. Ichikawa and C. Keith and William Arbuthnot Sir Lane and S. Schreiber},
  journal={Nature},
  year={1994},
  volume={369},
  pages={756-758}
}
  • E. Brown, M. W. Albers, +4 authors S. Schreiber
  • Published 1994
  • Biology, Medicine
  • Nature
    • THE structurally related natural products rapamycin and FK506 bind to the same intracellular receptor, FKBP12, yet the resulting complexes interfere with distinct signalling pathways1,2. FKBP12–rapamycin inhibits progression through the Gl phase of the cell cycle in osteosarcoma3, liver4, 5 and T cells6, 7 as well as in yeast8 and interferes with mitogenic signalling pathways that are involved in Gl progression9, 10 namely with activation of the protein p70S6k (refs 5,11–13) and cyclin… CONTINUE READING
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    References

    SHOWING 1-10 OF 27 REFERENCES
    Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
    • 1,689
    Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase
    • 563
    FKBP-rapamycin inhibits a cyclin-dependent kinase activity and a cyclin D1-Cdk association in early G1 of an osteosarcoma cell line.
    • 144
    • PDF
    Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases
    • 1,067
    Calcineurin mediates inhibition by FK506 and cyclosporin of recovery from α-factor arrest in yeast
    • 181
    Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity.
    • 288
    • PDF
    Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression
    • 798
    p70s6k function is essential for G1 progression
    • 338
    Rapamycin-induced inhibition of p34cdc2 kinase activation is associated with G1/S-phase growth arrest in T lymphocytes.
    • 175
    Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.
    • 588
    • PDF