A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation
@article{Grlich1992AMH, title={A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation}, author={D. G{\"o}rlich and S. Prehn and E. Hartmann and Kai-Uwe Kalies and T. Rapoport}, journal={Cell}, year={1992}, volume={71}, pages={489-503} }
SEC61p is essential for protein translocation across the endoplasmic reticulum membrane of S. cerevisiae. We have found a mammalian homolog that shows more than 50% sequence identity with the yeast protein. Moreover, several regions of SEC61p have significant similarities with corresponding ones of SecYp of bacteria, indicating a strong evolutionary conservation of the mechanism of protein translocation. Mammalian Sec61p, like the yeast protein, is located in the immediate vicinity of nascent… CONTINUE READING
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