A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation

@article{Grlich1992AMH,
  title={A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation},
  author={D. G{\"o}rlich and S. Prehn and E. Hartmann and Kai-Uwe Kalies and T. Rapoport},
  journal={Cell},
  year={1992},
  volume={71},
  pages={489-503}
}
  • D. Görlich, S. Prehn, +2 authors T. Rapoport
  • Published 1992
  • Biology, Medicine
  • Cell
  • SEC61p is essential for protein translocation across the endoplasmic reticulum membrane of S. cerevisiae. We have found a mammalian homolog that shows more than 50% sequence identity with the yeast protein. Moreover, several regions of SEC61p have significant similarities with corresponding ones of SecYp of bacteria, indicating a strong evolutionary conservation of the mechanism of protein translocation. Mammalian Sec61p, like the yeast protein, is located in the immediate vicinity of nascent… CONTINUE READING
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