A mammalian activity required for the second step of pre-messenger RNA splicing.

@article{Lindsey1995AMA,
  title={A mammalian activity required for the second step of pre-messenger RNA splicing.},
  author={Laurie Lindsey and Austin J Crow and Mariano A. Garcia-Blanco},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 22},
  pages={13415-21}
}
Splicing of precursors to messenger RNAs occurs via a two-step mechanism. In the first step, the 5'-exon is released concomitant with the production of a lariat intermediate, and in the second step, the exons are joined, releasing the intron in the form of a lariat product. Several gene products of the yeast Saccharomyces cerevisiae have been shown to be required exclusively for the second step. Although mammalian proteins have been implicated in the second step of splicing, none have been… CONTINUE READING

From This Paper

Topics from this paper.