A malignant neoplasm with features of both squamous cell carcinoma and malignant melanoma.

@article{Rosen1984AMN,
  title={A malignant neoplasm with features of both squamous cell carcinoma and malignant melanoma.},
  author={Les B. Rosen and W. D. Williams and Jacqueline Benson and A M Rywlin},
  journal={The American Journal of dermatopathology},
  year={1984},
  volume={6 Suppl},
  pages={213-9}
}
A case of a malignant neoplasm with features suggestive of both malignant melanoma and squamous cell carcinoma is reported. The neoplastic cells were positive for both S-100 protein and keratin when stained by the indirect peroxidase-antiperoxidase method. The literature on other instances of bi- or multidirectional differentiation of neoplastic cells is reviewed. The significance of these findings for terminology of neoplasms is discussed. 

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