A malignant cellular network in gliomas: potential clinical implications.

  title={A malignant cellular network in gliomas: potential clinical implications.},
  author={Matthias Osswald and Gergely M Solecki and Wolfgang Wick and Frank Winkler},
  volume={18 4},
The recent discovery of distinct, ultra-long, and highly functional membrane protrusions in gliomas, particularly in astrocytomas, extends our understanding of how these tumors progress in the brain and how they resist therapies. In this article, we will focus on ideas on how to target these membrane protrusions, for which we have suggested the term "tumor microtubes" (TMs), and the malignant multicellular network they form. First, we discuss TM-specific features and their differential… CONTINUE READING
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