A male murine model of partial bladder outlet obstruction reveals changes in detrusor morphology, contractility and Myosin isoform expression.

@article{Austin2004AMM,
  title={A male murine model of partial bladder outlet obstruction reveals changes in detrusor morphology, contractility and Myosin isoform expression.},
  author={Johanna Austin and Samuel K Chacko and Michael E Disanto and Douglas A. Canning and Stephen A. Zderic},
  journal={The Journal of urology},
  year={2004},
  volume={172 4 Pt 1},
  pages={1524-8}
}
PURPOSE Mice with gene deletion or targeted over expression are important for understanding the remodeling that follows partial bladder outlet obstruction (PBOO). This condition predominates in males. We produced PBOO in male mice and now report the physiological, histological and molecular consequences. MATERIALS AND METHODS Male C57bl/6 mice were surgically obstructed or subjected to sham surgery and unoperated mice served as controls. Four weeks later the bladders were excised and their… CONTINUE READING
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