A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum.

@article{Rosenthal1988AMC,
  title={A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum.},
  author={Philip J. Rosenthal and James H McKerrow and Masamichi Aikawa and Hiromichi Nagasawa and J. H. Leech},
  journal={The Journal of clinical investigation},
  year={1988},
  volume={82 5},
  pages={1560-6}
}
To obtain free amino acids for protein synthesis, trophozoite stage malaria parasites feed on the cytoplasm of host erythrocytes and degrade hemoglobin within an acid food vacuole. The food vacuole appears to be analogous to the secondary lysosomes of mammalian cells. To determine the enzymatic mechanism of hemoglobin degradation, we incubated trophozoite-infected erythrocytes with peptide inhibitors of different classes of proteinases. Leupeptin and L-transepoxy-succinyl-leucyl-amido-(4… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 85 extracted citations

Similar Papers

Loading similar papers…