A malarial cysteine protease is necessary for Plasmodium sporozoite egress from oocysts

@article{Aly2005AMC,
  title={A malarial cysteine protease is necessary for Plasmodium sporozoite egress from oocysts},
  author={Ahmed S I Aly and Kai Matuschewski},
  journal={The Journal of Experimental Medicine},
  year={2005},
  volume={202},
  pages={225 - 230}
}
The Plasmodium life cycle is a sequence of alternating invasive and replicative stages within the vertebrate and invertebrate hosts. How malarial parasites exit their host cells after completion of reproduction remains largely unsolved. Inhibitor studies indicated a role of Plasmodium cysteine proteases in merozoite release from host erythrocytes. To validate a vital function of malarial cysteine proteases in active parasite egress, we searched for target genes that can be analyzed functionally… CONTINUE READING

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