A malaria parasite formin regulates actin polymerization and localizes to the parasite-erythrocyte moving junction during invasion.

@article{Baum2008AMP,
  title={A malaria parasite formin regulates actin polymerization and localizes to the parasite-erythrocyte moving junction during invasion.},
  author={Jake Baum and Christopher J. Tonkin and Aditya S. Paul and Melanie Rug and Brian J. Smith and Sven B Gould and D. D. Richard and Thomas D. Pollard and Alan F Cowman},
  journal={Cell host & microbe},
  year={2008},
  volume={3 3},
  pages={188-98}
}
Malaria parasites invade host cells using actin-based motility, a process requiring parasite actin filament nucleation and polymerization. Malaria and other apicomplexan parasites lack Arp2/3 complex, an actin nucleator widely conserved across eukaryotes, but do express formins, another type of actin nucleator. Here, we demonstrate that one of two malaria parasite formins, Plasmodium falciparum formin 1 (PfFormin 1), and its ortholog in the related parasite Toxoplasma gondii, follows the moving… CONTINUE READING
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