A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation.

@article{Ke2015AMO,
  title={A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation.},
  author={Shengdong Ke and Endalkachew Ashenafi Alemu and Claudia Mertens and Emily Conn Gantman and John J. Fak and Aldo Mele and Bhagwattie Haripal and Ilana Zucker-Scharff and Michael J. Moore and Christopher Y Park and Cathrine Broberg V{\aa}gb\o and Anna Kusśnierczyk and Arne Klungland and J. E. Darnell and Robert B Darnell},
  journal={Genes & development},
  year={2015},
  volume={29 19},
  pages={2037-53}
}
We adapted UV CLIP (cross-linking immunoprecipitation) to accurately locate tens of thousands of m(6)A residues in mammalian mRNA with single-nucleotide resolution. More than 70% of these residues are present in the 3'-most (last) exons, with a very sharp rise (sixfold) within 150-400 nucleotides of the start of the last exon. Two-thirds of last exon m(6)A and >40% of all m(6)A in mRNA are present in 3' untranslated regions (UTRs); contrary to earlier suggestions, there is no preference for… CONTINUE READING
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