A major thyroid hormone response element in the third intron of the rat growth hormone gene.

@article{Sap1990AMT,
  title={A major thyroid hormone response element in the third intron of the rat growth hormone gene.},
  author={Jan Sap and L de Magistris and Hendrik G. Stunnenberg and Bj{\"o}rn Vennstr{\"o}m},
  journal={The EMBO journal},
  year={1990},
  volume={9 3},
  pages={887-96}
}
The rat growth hormone (RGH) gene constitutes a well-documented model system for the direct regulation of transcription by thyroid hormones. In order to analyse its interaction with sequences in the RGH gene, we have overproduced the thyroid hormone receptor-alpha (c-erbA) protein using a vaccinia virus expression system. The expressed protein bound T3 and DNA-cellulose with expected affinities, and the major binding site for the receptor protein was found to be located in the third intron of… CONTINUE READING

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