A major susceptibility locus for leprosy in India maps to chromosome 10p13

@article{Siddiqui2001AMS,
  title={A major susceptibility locus for leprosy in India maps to chromosome 10p13},
  author={Mahveen Ruby Siddiqui and Sarah Meisner and Kerrie Tosh and Karuppiah Balakrishnan and Satish Ghei and Simon E. Fisher and Marina Golding and Nallakandy P. Shanker Narayan and Thiagarajan Sitaraman and Uttpal Sengupta and Ramasamy M. Pitchappan and Adrian V S Hill},
  journal={Nature Genetics},
  year={2001},
  volume={27},
  pages={439-441}
}
Leprosy, a chronic infectious disease caused by Mycobacterium leprae, is prevalent in India, where about half of the world's estimated 800,000 cases occur. A role for the genetics of the host in variable susceptibility to leprosy has been indicated by familial clustering, twin studies, complex segregation analyses and human leukocyte antigen (HLA) association studies. We report here a genetic linkage scan of the genomes of 224 families from South India, containing 245 independent affected… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 78 extracted citations

Pauci- and Multibacillary Leprosy: Two Distinct, Genetically Neglected Diseases

PLoS neglected tropical diseases • 2016
View 18 Excerpts
Highly Influenced

Leprosy and the human genome.

Microbiology and molecular biology reviews : MMBR • 2010
View 7 Excerpts
Highly Influenced

Leprosy as a genetic disease

View 1 Excerpt
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 29 references

Genetic susceptibility to tuberculosis in Africans: a genome-wide scan.

Proceedings of the National Academy of Sciences of the United States of America • 2000

a genomewide scan

Bellamy, R. et al. Genetic susceptibility to tuberculosis in Africans
Proc. Natl. Acad. Sci. USA 97, 8005–8009 • 2000

Plasmodium falciparum blood infection levels are linked to chromosome 5q31–q33

Rihet, P. et al. Malaria in humans
Am. J. Hum. Genet. 63, 498–505 • 1998

WHO Elimination of leprosy as a public health problem . Wkly Epidemiol

S. P. Aredath
1998

Similar Papers

Loading similar papers…