A major susceptibility locus for leprosy in India maps to chromosome 10p13

  title={A major susceptibility locus for leprosy in India maps to chromosome 10p13},
  author={Mahveen Ruby Siddiqui and Sarah Meisner and Kerrie Tosh and Karuppiah Balakrishnan and Satish Ghei and Simon E. Fisher and Marina Golding and Nallakandy P. Shanker Narayan and Thiagarajan Sitaraman and Uttpal Sengupta and Ramasamy M. Pitchappan and Adrian V S Hill},
  journal={Nature Genetics},
Leprosy, a chronic infectious disease caused by Mycobacterium leprae, is prevalent in India, where about half of the world's estimated 800,000 cases occur. A role for the genetics of the host in variable susceptibility to leprosy has been indicated by familial clustering, twin studies, complex segregation analyses and human leukocyte antigen (HLA) association studies. We report here a genetic linkage scan of the genomes of 224 families from South India, containing 245 independent affected… CONTINUE READING

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