A major role of p95/611-CTF, a carboxy-terminal fragment of HER2, in the down-modulation of the estrogen receptor in HER2-positive breast cancers.

@article{ParraPalau2010AMR,
  title={A major role of p95/611-CTF, a carboxy-terminal fragment of HER2, in the down-modulation of the estrogen receptor in HER2-positive breast cancers.},
  author={Josep Llu{\'i}s Parra-Palau and Kim Pedersen and Vicente Peg and Maurizio Scaltriti and Pier Davide Angelini and Marta Escorihuela and S. Mancilla and Alexandre S{\'a}nchez Pla and Santiago Ramon Y Cajal and Jos{\'e} Baselga and Joaqu{\'i}n Arribas},
  journal={Cancer research},
  year={2010},
  volume={70 21},
  pages={8537-46}
}
Current classification of breast cancers depends in great part on the expression of human epidermal growth factor receptor 2 (HER2), a cell surface tyrosine kinase receptor, and estrogen receptor (ER), the nuclear receptor for estrogen. In addition to reliable biomarkers, these receptors are targets of effective and widely used antitumor drugs. During malignant progression, HER2 and ER can establish an intricate cross-talk. In some cases, HER2 overexpression leads to the downregulation of ER… CONTINUE READING

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