A major role for thalamocortical afferents in serotonergic hallucinogen receptor function in the rat neocortex

  title={A major role for thalamocortical afferents in serotonergic hallucinogen receptor function in the rat neocortex},
  author={Gerard J. Marek and Rebecca A. Wright and Jonathan C. Gewirtz and Darryle D. Schoepp},

Interactions of Hallucinogens with the Glutamatergic System: Permissive Network Effects Mediated Through Cortical Layer V Pyramidal Neurons.

  • G. Marek
  • Biology
    Current topics in behavioral neurosciences
  • 2018
The effects on 5-HT2A receptors and related GPCRs appear to play a major role in the behavioral effects of serotonergic hallucinogens, such as head twitches in rodents and higher order behaviors such as rodent lever pressing on the differential-reinforcement-of-low rate 72-s (DRL72-s) schedule.

Mechanism of the 5-hydroxytryptamine 2A receptor-mediated facilitation of synaptic activity in prefrontal cortex

The results from these experiments do not support the idea that 5-HT2ARs elicit the release of an excitatory retrograde messenger nor that they activate thalamocortical afferents, the two dominant hypotheses, and suggest that5-HT 2ARs facilitate intrinsic networks within the PFC.

Control of the serotonergic system by the medial prefrontal cortex: Potential role in the etiology of PTSD and depressive disorders

Data indicate that the activity of the 5-HT system is strongly controlled by the mPFC, and the abnormal prefrontal function in post-traumatic stress disorder and depressive patients may induce a disregulation of 5- HT neurons projecting to other brain areas that can underlie the existing symptomatology in these psychiatric disorders.

Orexin 2 Receptor Antagonists from Prefrontal Cortical Circuitry to Rodent Behavioral Screens

The treatment of mood disorders is an additional potential indica-tion for orexin receptor antagonists beyond simply improving sleep by suppressing hallucinogen-induced head twitches and producing antidepressant-like effects on the differential-reinforcement-of-low-rate 72-s (DRL72-s) schedule of reinforcement.

Presynaptic serotonin 2A receptors modulate thalamocortical plasticity and associative learning

The results provide the first physiological evidence of a role of presynaptic 5-HT2A receptors located at thalamocortical synapses in the control of thalamofrontal connectivity and the associated cognitive functions.

Effects of Hallucinogens on Neuronal Activity.

The disruption of PFC activity induced by PCP, DOI and 5-MeO-DMT is reversed by classical and atypical antipsychotic drugs, suggesting a possible link between the mechanisms underlying the disruption of perception by multiple classes of hallucinogenic agents and the therapeutic efficacy of antipsychotics.

The activation of 5-HT2A receptors in medial prefrontal cortex (mPFC) by the hallucinogen DOI increases the firing activity of dorsal raphe

It is concluded that DOI increases the activity of the mPFC-DR circuit by an action on postsynaptic 5-HT2A receptors unrelated to thalamocortical afferents.



5-Hydroxytryptamine2A serotonin receptors in the primate cerebral cortex: possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites.

These findings reconcile the data on the receptor's cortical physiology and localization by establishing that 5-HT2A receptors are located postsynaptically and presynaptically, and demonstrating that pyramidal neurons constitute the major 5- HT2A-receptor-expressing cells in the cortex, and supporting the view that the apical dendritic field proximal to the pyramsidal cell soma is the "hot spot" for 5-ht2A's physiological actions.

DOI-Induced Activation of the Cortex: Dependence on 5-HT2A Heteroceptors on Thalamocortical Glutamatergic Neurons

It is found that DOI did not induce Fos in cortical 5-HT2A immunoreactive neurons but did increase expression in a band of neurons spanning superficial layer V to deep III, within the apical dendritic fields of layer V 5- HT2A-immunoreactive cells.

Physiological antagonism between 5-hydroxytryptamine(2A) and group II metabotropic glutamate receptors in prefrontal cortex.

A close coupling between mGlu2/3 and 5-HT(2A) receptors in the prefrontal cortex that may be relevant for novel therapeutic approaches in the treatment of neuropsychiatric syndromes such as depression and schizophrenia is suggested.

Comparative localization of serotonin1A, 1C, and 2 receptor subtype mRNAs in rat brain

The results of this study demonstrate that nervous which express these 5‐HT receptor subtypes are very widespread in the central nervous system, yet possess unique distributions with in the rat brain, which leads to the possibility that individual cells may express more than one 5‐ HT receptor subtype.

Neuroanatomical patterns of the mu, delta, and kappa opioid receptors of rat brain as determined by quantitative in vitro autoradiography.

  • A. TempelR. Zukin
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1987
The present study concludes that delta receptors occur at high density only in the forebrain and in two midbrain structures, whereas mu and kappa receptors exhibit discrete patterns in most major brain regions.

Subcellular distribution of 5‐hydroxytryptamine2A and N‐methyl‐D‐aspartate receptors within single neurons in rat motor and limbic striatum

Results indicate that 5HT2A and NMDA receptors are coexpressed but differentially targeted in single spiny striatal neurons and are likely to play a major role in control of motor functions involving the dorsolateral CPN.