A major role for neutrophils in experimental bullous pemphigoid.

  title={A major role for neutrophils in experimental bullous pemphigoid.},
  author={Zhi Song Liu and George J. Giudice and Xiaoye Zhou and Sarah J Swartz and Julia L. Troy and Janet A. Fairley and Gerd O. Till and Luis A Diaz},
  journal={The Journal of clinical investigation},
  volume={100 5},
Bullous pemphigoid (BP) is an inflammatory subepidermal blistering disease associated with an IgG autoimmune response to the hemidesmosomal protein, BP180. Using a passive transfer mouse model, our group has shown previously that antibodies to the murine BP180 (mBP180) ectodomain are capable of triggering a blistering skin disease that closely mimics human BP. In this study, we investigated the role of neutrophils in the immunopathogenesis of this disease model. BALB/c mice depleted of… CONTINUE READING


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Histologic Diagnosis of Inflammatory Skin Diseases. 2nd Edition

  • A. B. Ackerman, N. Chongchitnant, +4 authors M. B. Randal
  • 1997

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