A major role for HERG in determining frequency of reentry in neonatal rat ventricular myocyte monolayer.

@article{Hou2010AMR,
  title={A major role for HERG in determining frequency of reentry in neonatal rat ventricular myocyte monolayer.},
  author={Luqia Hou and Makarand Deo and Philip B Furspan and Sandeep V. Pandit and Sergey Mironov and David S. Auerbach and Qiuming Gong and Zhengfeng Zhou and Omer Berenfeld and Jos{\'e} Jalife},
  journal={Circulation research},
  year={2010},
  volume={107 12},
  pages={1503-11}
}
RATIONALE the rapid delayed rectifier potassium current, I(Kr), which flows through the human ether-a-go-go-related (hERG) channel, is a major determinant of the shape and duration of the human cardiac action potential (APD). However, it is unknown whether the time dependency of I(Kr) enables it to control APD, conduction velocity (CV), and wavelength (WL) at the exceedingly high activation frequencies that are relevant to cardiac reentry and fibrillation. OBJECTIVE to test the hypothesis… CONTINUE READING
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Basic Cardiac Electrophysiology for the Clinician

  • J Jalife, M Delmar, J Anumonwo, O Berenfeld, J Kalifa, eds
  • 2009
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