A major metabolite of Δ1-tetrahydrocannabinol reduces its cataleptic effect in mice

@article{Burstein2005AMM,
  title={A major metabolite of $\Delta$1-tetrahydrocannabinol reduces its cataleptic effect in mice},
  author={Sumner H Burstein and Sheila A. Hunter and V Latham and L A Renzulli},
  journal={Experientia},
  year={2005},
  volume={43},
  pages={402-403}
}
The results described here demonstrate that THC-induced catalepsy in mice can be substantially inhibited by the prior administration of Δ1-THC-7-oic acid, the major metabolite of THC in most species including humans. This raises the possibility that the intensity and duration of action of THC may depend to a large degree on the levels of this metabolite at the sites of action. 
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13 Citations

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Clinical Pharmacokinetics of Cannabinoids

ABSTRACT Absorption and metabolism of tetrahydrocannabinol (THC) vary as a function of route of administration. Pulmonary assimilation of inhaled THC causes a maximum plasma concentration within mi...

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Cannabinoids for therapeutic use

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