A major metabolite of Δ1-tetrahydrocannabinol reduces its cataleptic effect in mice
@article{Burstein2005AMM, title={A major metabolite of Δ1-tetrahydrocannabinol reduces its cataleptic effect in mice}, author={S. Burstein and S. Hunter and V. Latham and L. Renzulli}, journal={Experientia}, year={2005}, volume={43}, pages={402-403} }
The results described here demonstrate that THC-induced catalepsy in mice can be substantially inhibited by the prior administration of Δ1-THC-7-oic acid, the major metabolite of THC in most species including humans. This raises the possibility that the intensity and duration of action of THC may depend to a large degree on the levels of this metabolite at the sites of action.
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