A major metabolite of Δ1-tetrahydrocannabinol reduces its cataleptic effect in mice

  title={A major metabolite of Δ1-tetrahydrocannabinol reduces its cataleptic effect in mice},
  author={S. Burstein and S. Hunter and V. Latham and L. Renzulli},
  • S. Burstein, S. Hunter, +1 author L. Renzulli
  • Published 2005
  • Chemistry
  • Experientia
  • The results described here demonstrate that THC-induced catalepsy in mice can be substantially inhibited by the prior administration of Δ1-THC-7-oic acid, the major metabolite of THC in most species including humans. This raises the possibility that the intensity and duration of action of THC may depend to a large degree on the levels of this metabolite at the sites of action. 
    11 Citations

    Tables from this paper

    The cannabinoid acids, analogs and endogenous counterparts.
    • S. Burstein
    • Chemistry, Medicine
    • Bioorganic & medicinal chemistry
    • 2014
    • 14
    • PDF
    Clinical Pharmacodynamics of Cannabinoids
    • 28
    • PDF
    Pharmacokinetics and Pharmacodynamics of Cannabinoids
    • 832
    • PDF
    Clinical Pharmacokinetics of Cannabinoids
    • 33
    • PDF
    Cannabinoids for therapeutic use
    • 14


    Prostaglandins and cannabis XIV. Tolerance to the stimulatory actions of cannabinoids on arachidonate metabolism.
    • 17
    Anti-edema and analgesic properties of delta9-tetrahydrocannabinol (THC).
    • 113
    The ring test: a quantitative method for assessing the ‘cataleptic’ effect of cannabis in mice
    • R. Pertwee
    • Chemistry, Medicine
    • British journal of pharmacology
    • 1972
    • 183
    • PDF
    Marihuana: Biological Effects
    • 1979