A major inhibitor of phenytoin binding to serum protein in uremia.

@article{Mabuchi1988AMI,
  title={A major inhibitor of phenytoin binding to serum protein in uremia.},
  author={Hiroshi Mabuchi and Hisashi Nakahashi},
  journal={Nephron},
  year={1988},
  volume={48 4},
  pages={310-4}
}
A major endogenous ligand substance, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), accumulated in the sera of uremic patients, inhibited phenytoin binding to pooled serum obtained from healthy subjects and to human serum albumin in a concentration usually observed in the sera of patients with uremia. This suggests that CMPF is a major drug-binding inhibitor present in uremic serum and may be one of the so-called 'uremic toxins'.