A major human arsenic metabolite, dimethylarsinic acid, requires reduced glutathione to induce apoptosis.

@article{Sakurai2002AMH,
  title={A major human arsenic metabolite, dimethylarsinic acid, requires reduced glutathione to induce apoptosis.},
  author={Teruaki Sakurai and Wei Qu and Masumi H. Sakurai and Michael P. Waalkes},
  journal={Chemical research in toxicology},
  year={2002},
  volume={15 5},
  pages={
          629-37
        }
}
  • Teruaki Sakurai, Wei Qu, +1 author Michael P. Waalkes
  • Published in
    Chemical research in…
    2002
  • Chemistry, Medicine
  • Inorganic arsenicals are important environmental toxicants and carcinogens in humans. In mammals, including humans, inorganic arsenicals often undergo methylation, forming compounds such as dimethyarsinic acid (DMA). Recent evidence indicates DMA is a complete carcinogen in rodents while evidence for inorganic arsenicals as carcinogens in rodents remains equivocal. Thus, we studied the molecular mechanisms of in vitro cytolethality of DMA compared to that of the trivalent inorganic arsenical… CONTINUE READING

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