A major gene affecting age-related hearing loss is common to at least ten inbred strains of mice.

@article{Johnson2000AMG,
  title={A major gene affecting age-related hearing loss is common to at least ten inbred strains of mice.},
  author={K. R. Johnson and Qing Yin Zheng and Lawrence C. Erway},
  journal={Genomics},
  year={2000},
  volume={70 2},
  pages={
          171-80
        }
}
Inbred strains of mice offer promising models for understanding the genetic basis of human presbycusis or age-related hearing loss (AHL). We previously mapped a major gene affecting AHL in C57BL/6J mice. Here, we show that the same Chromosome 10 gene (Ahl) is a major contributor to AHL in nine other inbred mouse strains-129P1/ReJ, A/J, BALB/cByJ, BUB/BnJ, C57BR/cdJ, DBA/2J, NOD/LtJ, SKH2/J, and STOCK760. F1 hybrids between each of these inbred strains and the normal-hearing inbred strain CAST… Expand
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The genetic mapping of a second AHL locus in mice (designated Ahl2) that is a major contributor to the 8- to 10-month difference in hearing loss onset times between NOD/LtJ and C57BL/6J mice is reported. Expand
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It is concluded that ahl8 is a major contributor to the hearing loss of DBA/2J mice and that its effects are dependent on the predisposing Cdh23 ahl genotype of this strain. Expand
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All of the available evidence supports a role for the Ahl gene in both AHL and NIHL among these strains of mice, and segregation for the putative Ahl genes and mapping of such a gene to Chromosome 10 are demonstrated. Expand
A locus on distal chromosome 10 (ahl4) affecting age-related hearing loss in A/J mice
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Rec recombinant inbred strains, chromosome substitution strains, and a linkage backcross are used to map a locus on distal Chromosome 10, designated ahl4, that contributes to the early-onset hearing loss of A/J mice. Expand
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Hearing loss associated with the modifier of deaf waddler (mdfw) locus corresponds with age-related hearing loss in 12 inbred strains of mice
TLDR
The hearing loss associated with these strain-specific mdfW alleles corresponds with previously determined Ahl allele effects, providing additional evidence that mdfw and Ahl are manifestations of the same gene. Expand
A Chromosome 17 Locus Engenders Frequency-Specific Non-Progressive Hearing Loss that Contributes to Age-Related Hearing Loss in Mice
TLDR
A region of proximal chromosome (Chr) 17 (D17Mit143-D 17Mit100) that contributes to a sensory, non-progressive hearing loss (NPHL) affecting exclusively the high-frequencies (>24 kHz) and maps to the nr1 locus on Chr 17. Expand
Ahl3, a third locus on mouse chromosome 17 affecting age-related hearing loss.
TLDR
Mapping of an AHL locus using a panel of consomic mice between C57BL/6J (B6) and MSM strains, which covered more than a half of chromosome sets, shows a novel AHL-resistant locus, designated as Ahl3, on the chromosome 17. Expand
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