A major chromatin regulator determines resistance of tumor cells to T cell–mediated killing

@article{Pan2018AMC,
  title={A major chromatin regulator determines resistance of tumor cells to T cell–mediated killing},
  author={Deng Pan and Aya Kobayashi and Peng Jiang and Lucas Ferrari de Andrade and Rong En Tay and Adrienne M Luoma and Daphne Tsoucas and Xintao Qiu and Klothilda Lim and Prakash K. Rao and Henry W. Long and Guocheng Yuan and John G Doench and Myles Brown and Xiaole Shirley Liu and Kai W Wucherpfennig},
  journal={Science},
  year={2018},
  volume={359},
  pages={770-775}
}
Many human cancers are resistant to immunotherapy, for reasons that are poorly understood. We used a genome-scale CRISPR-Cas9 screen to identify mechanisms of tumor cell resistance to killing by cytotoxic T cells, the central effectors of antitumor immunity. Inactivation of >100 genes—including Pbrm1, Arid2, and Brd7, which encode components of the PBAF form of the SWI/SNF chromatin remodeling complex—sensitized mouse B16F10 melanoma cells to killing by T cells. Loss of PBAF function increased… CONTINUE READING
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