A major bristle QTL from a selected population of Drosophila uncovers the zinc-finger transcription factor poils-au-dos, a repressor of achaete-scute.

@article{Gibert2005AMB,
  title={A major bristle QTL from a selected population of Drosophila uncovers the zinc-finger transcription factor poils-au-dos, a repressor of achaete-scute.},
  author={Jean-Michel Gibert and Sylvain Marcellini and Jean Robert David and Christian Schl{\"o}tterer and Pat Simpson},
  journal={Developmental biology},
  year={2005},
  volume={288 1},
  pages={194-205}
}
Traditional screens aiming at identifying genes regulating development have relied on mutagenesis. Here, we describe a new gene involved in bristle development, identified through the use of natural variation and selection. Drosophila melanogaster bears a pattern of 11 macrochaetes per heminotum. From a population initially sampled in Marrakech, a strain was selected for an increased number of thoracic macrochaetes. Using recombination and single nucleotide polymorphisms, the factor responsible… CONTINUE READING