A magnetization transfer histogram study of normal-appearing brain tissue in MS.

@article{Tortorella2000AMT,
  title={A magnetization transfer histogram study of normal-appearing brain tissue in MS.},
  author={Carla Tortorella and Barbara Viti and Marco Bozzali and Maria Pia Sormani and Giovanni Rizzo and M F Gilardi and Giancarlo Comi and Massimo Filippi},
  journal={Neurology},
  year={2000},
  volume={54 1},
  pages={186-93}
}
OBJECTIVE To evaluate 1) the ability of magnetization transfer ratio (MTR) histogram analysis to detect the extent of changes occurring outside MS lesions seen on conventional scans, 2) whether such changes vary in the different MS clinical phenotypes, 3) whether the changes are associated with the extent and severity of the macroscopic lesion load, and 4) the contribution to brain atrophy. METHODS Dual-echo, T1-weighted, and MT scans of the brain were obtained from 77 patients with varying… CONTINUE READING
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