A macrophage receptor for apolipoprotein B48: cloning, expression, and atherosclerosis.

@article{Brown2000AMR,
  title={A macrophage receptor for apolipoprotein B48: cloning, expression, and atherosclerosis.},
  author={Matthew L. Brown and Mysore P. Ramprasad and Patrick K. Umeda and Atsushi Tanaka and Yoichi Kobayashi and Takehiko Watanabe and Hiroaki Shimoyamada and Wei Liang Kuo and Rui-fang Li and Ruiping Song and William Aspenwall Bradley and Sandra H. Gianturco},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 13},
  pages={
          7488-93
        }
}
We have cloned a human macrophage receptor that binds to apolipoprotein (apo)B48 of dietary triglyceride (TG)-rich lipoproteins. TG-rich lipoprotein uptake by the apoB48R rapidly converts macrophages and apoB48R-transfected Chinese hamster ovary cells in vitro into lipid-filled foam cells, as seen in atherosclerotic lesions. The apoB48R cDNA (3,744 bp) encodes a protein with no known homologs. Its approximately 3.8-kb mRNA is expressed primarily by reticuloendothelial cells: monocytes… CONTINUE READING

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