A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines.

@article{Farber1990AMM,
  title={A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines.},
  author={Joshua M Farber},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 14},
  pages={5238-42}
}
  • Joshua M Farber
  • Published 1990 in
    Proceedings of the National Academy of Sciences…
In order to identify novel mediators synthesized in activated macrophages, a cDNA library was prepared from cultures of the mouse macrophage cell line RAW 264.7 that had been treated with lymphokine-rich conditioned medium from mitogen-stimulated mouse spleen cells. Differential plaque hybridization identified a cDNA, designated m119, that detected a 1.6-kilobase mRNA that accumulated in response to gamma-interferon (IFN-gamma) but not in response to other macrophage activators, including IFN… CONTINUE READING
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