A macromolecular complex of beta 2 adrenergic receptor, CFTR, and ezrin/radixin/moesin-binding phosphoprotein 50 is regulated by PKA.

@article{Naren2003AMC,
  title={A macromolecular complex of beta 2 adrenergic receptor, CFTR, and ezrin/radixin/moesin-binding phosphoprotein 50 is regulated by PKA.},
  author={Anjaparavanda P Naren and Bryan R Cobb and Chunying Li and Koushik Roy and David Nelson and Ghanshyam D. Heda and Jie Liao and Kevin L. Kirk and Eric Sorscher and John W. Hanrahan and John P Clancy},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 1},
  pages={342-6}
}
It has been demonstrated previously that both the cystic fibrosis transmembrane conductance regulator (CFTR) and beta(2) adrenergic receptor (beta(2)AR) can bind ezrinradixinmoesin-binding phosphoprotein 50 (EBP50, also referred to as NHERF) through their PDZ motifs. Here, we show that beta(2) is the major adrenergic receptor isoform expressed in airway epithelia and that it colocalizes with CFTR at the apical membrane. beta(2)AR stimulation increases CFTR activity, in airway epithelial cells… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 79 extracted citations

Stimulation of β2-adrenergic receptor increases CFTR function and decreases ATP levels in murine hematopoietic stem/progenitor cells.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society • 2015
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.

Similar Papers

Loading similar papers…