A mRNA signal for the type III secretion of Yop proteins by Yersinia enterocolitica.

@article{Anderson1997AMS,
  title={A mRNA signal for the type III secretion of Yop proteins by Yersinia enterocolitica.},
  author={Deborah M. Anderson and Olaf Schneewind},
  journal={Science},
  year={1997},
  volume={278 5340},
  pages={
          1140-3
        }
}
Pathogenic Yersinia species have a specialized secretion system (type III) to target cytotoxic Yop proteins during infection. The signals of YopE and YopN sufficient for the secretion of translational reporter fusions were mapped to the first 15 codons. No common amino acid or peptide sequence could be identified among the secretion signals. Systematic mutagenesis of the secretion signal yielded mutants defective in Yop translation; however, no point mutants could be identified that… CONTINUE READING
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