A lymphocyte-specific enhancer in the mouse immunoglobulin kappa gene.

@article{Picard1984ALE,
  title={A lymphocyte-specific enhancer in the mouse immunoglobulin kappa gene.},
  author={Didier Picard and Walter Schaffner},
  journal={Nature},
  year={1984},
  volume={307 5946},
  pages={80-2}
}
During differentiation of lymphocytes into antibody-producing cells, an immunoglobulin kappa variable-region gene is transcriptionally activated by rearrangement linking it to a kappa constant (C kappa) region gene which is already transcribed prior to somatic rearrangement. The presence of a transcriptional enhancer element within the large intron of the kappa light-chain gene has been postulated to explain this mode of activation, supported by evidence of a chromatin region which is… CONTINUE READING

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