A luminal flavoprotein in endoplasmic reticulum-associated degradation.

  title={A luminal flavoprotein in endoplasmic reticulum-associated degradation.},
  author={Jan Riemer and Christian Appenzeller-Herzog and Linda Johansson and Bernd Bodenmiller and Rasmus Hartmann-Petersen and Lars Ellgaard},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 35},
The quality control system of the endoplasmic reticulum (ER) discriminates between native and nonnative proteins. The latter are degraded by the ER-associated degradation (ERAD) pathway. Whereas many cytosolic and membrane components of this system are known, only few luminal players have been identified. In this study, we characterize ERFAD (ER flavoprotein associated with degradation), an ER luminal flavoprotein that functions in ERAD. Upon knockdown of ERFAD, the degradation of the ERAD… CONTINUE READING
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