A lower proportion of filamentous to monomeric actin in the developing cerebellum of thyroid-deficient rats.

@article{FaivreSarrailh1988ALP,
  title={A lower proportion of filamentous to monomeric actin in the developing cerebellum of thyroid-deficient rats.},
  author={Catherine Faivre-Sarrailh and Alain Rabi{\'e}},
  journal={Brain research},
  year={1988},
  volume={469 1-2},
  pages={293-7}
}
Using a DNase I inhibition assay, in the presence or the absence of guanidine hydrochloride (which depolymerizes the actin filaments), developmental changes in total and filamentous actin were determined in the cerebellum of normal and hypothyroid rats. The total actin content per mg protein was not modified by hypothyroidism. As in normal animals, it reached a maximum around the age of 8 days and then decreased until adulthood. In contrast, the proportion of filamentous actin, which increased… CONTINUE READING

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