A low resolution model for the interaction of G proteins with G protein-coupled receptors.

@article{Oliveira1999ALR,
  title={A low resolution model for the interaction of G proteins with G protein-coupled receptors.},
  author={Lucas Hollanda Oliveira and A. C. M. Paiva and Gert Vriend},
  journal={Protein engineering},
  year={1999},
  volume={12 12},
  pages={1087-95}
}
A model is presented for the interaction between G proteins and G protein-coupled receptors. The model is based on the fact that this interaction shows little specificity and thus conserved parts of the G proteins have to interact with conserved parts of the receptors. These parts are a conserved negative residue in the G protein, a fully conserved arginine in the receptor and a series of residues that are not conserved but always hydrophobic like the hydrophobic side of the C-terminal helix of… CONTINUE READING

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