A low rate of nucleotide changes in Escherichia coli K-12 estimated from a comparison of the genome sequences between two different substrains.

@article{Itoh1999ALR,
  title={A low rate of nucleotide changes in Escherichia coli K-12 estimated from a comparison of the genome sequences between two different substrains.},
  author={Takehito Itoh and Takashi Okayama and Hiroshi Hashimoto and Jun Takeda and Ronald W. Davis and Hiroki Mori and Takashi Gojobori},
  journal={FEBS letters},
  year={1999},
  volume={450 1-2},
  pages={72-6}
}
Two genome sequences of Escherichia coli K-12 substrains, one partial W3110 and one complete MG1655, have been determined by Japanese and American genome projects, respectively. In order to estimate the rate of nucleotide changes, we directly compared 2 Mb of the nucleotide sequences from these closely-related E. coli substrains. Given that the two substrains separated about 40 years ago, the rate of nucleotide changes was estimated to be less than 10(-7) per site per year. This rate was… CONTINUE READING

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