A low-molecular-weight inhibitor against the chemokine receptor CXCR4: a strong anti-HIV peptide T140.

@article{Tamamura1998ALI,
  title={A low-molecular-weight inhibitor against the chemokine receptor CXCR4: a strong anti-HIV peptide T140.},
  author={Hirokazu Tamamura and Ying ming Xu and Takako Hattori and Xuemei Zhang and R P Arakaki and Keiko Kanbara and Akane Omagari and Akira Otaka and Toshiro Ibuka and Naoki Yamamoto and Hideki Nakashima and Nobutaka Fujii},
  journal={Biochemical and biophysical research communications},
  year={1998},
  volume={253 3},
  pages={
          877-82
        }
}
T22 ([Tyr5,12, Lys7]-polyphemusin II) is an 18-residue peptide amide, which has strong anti-HIV activity. T22 inhibits the T cell line-tropic (T-tropic) HIV-1 infection through its specific binding to a chemokine receptor CXCR4, which serves as a coreceptor for the entry of T-tropic HIV-1 strains. Herein, we report our finding of novel 14-residue CXCR4 inhibitors, T134 and T140, on the basis of the T22 structure. In the assays we examined, T140 showed the highest inhibitory activity against HIV… CONTINUE READING

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