A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells.

@article{Song2005ALC,
  title={A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells.},
  author={Hui Song and Renxiao Wang and Shaomeng Wang and Jiayuh Lin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 13},
  pages={
          4700-5
        }
}
This study focused on the screening of small-molecule inhibitors that target signal transducers and activators of transcription 3 (Stat3) in human breast carcinoma. The constitutive activation of Stat3 is frequently detected in human breast cancer cell lines as well as clinical breast cancer specimens and may play an important role in the oncogenesis of breast carcinoma. Activated Stat3 may participate in oncogenesis by stimulating cell proliferation, promoting tumor angiogenesis, and resisting… CONTINUE READING
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