A low-frequency variant at 8q24.21 is strongly associated with risk of oligodendroglial tumors and astrocytomas with IDH1 or IDH2 mutation

@article{Jenkins2012ALV,
  title={A low-frequency variant at 8q24.21 is strongly associated with risk of oligodendroglial tumors and astrocytomas with IDH1 or IDH2 mutation},
  author={R. Brian Jenkins and Yuanyuan Xiao and Hugues Sicotte and P. Anthony Decker and Thomas M. Kollmeyer and Helen M. Hansen and Matthew L. Kosel and Shichun Zheng and Kyle M. Walsh and Terri S Rice and Paige M. Bracci and Lucie S. McCoy and Ivan V. Smirnov and Joseph S. Patoka and George Hsuang and Joe L. Wiemels and Tarik Tihan and Alexander R. Pico and Michael D. Prados and Susan M. Chang and Mitchel S. Berger and Alissa A. Caron and Stephanie R. Fink and Chandralekha Halder and Amanda L Rynearson and Brooke L. Fridley and Jan C. Buckner and Brian P O'neill and Caterina Giannini and Daniel H. Lachance and John K. Wiencke and Jeanette E. Eckel-Passow and Margaret R. Wrensch},
  journal={Nature Genetics},
  year={2012},
  volume={44},
  pages={1122-1125}
}
Variants at 8q24.21 have been shown to be associated with glioma development. By means of tag SNP genotyping and imputation, pooled next-generation sequencing using long-range PCR and subsequent validation SNP genotyping, we identified seven low-frequency SNPs at 8q24.21 that were strongly associated with glioma risk (P = 1 × 10−25 to 1 × 10−14). The most strongly associated SNP, rs55705857, remained highly significant after individual adjustment for the other top six SNPs and two previously… CONTINUE READING