A low-cost method to test cytotoxic effects of Crotalus vegrandis (Serpentes: Viperidae) venom on kidney cell cultures.

@article{Girn2005ALM,
  title={A low-cost method to test cytotoxic effects of Crotalus vegrandis (Serpentes: Viperidae) venom on kidney cell cultures.},
  author={Mar{\'i}a Eugenia Gir{\'o}n and Irma Aguilar and Lisandro Romero and Montamas Suntravat and J Christian Perez and Alexis Rodr{\'i}guez-Acosta},
  journal={Revista do Instituto de Medicina Tropical de Sao Paulo},
  year={2005},
  volume={47 3},
  pages={
          147-52
        }
}
The pathogenesis of the renal lesion upon envenomation by snakebite has been related to myolysis, hemolysis, hypotension and/or direct venom nephrotoxicity caused by the venom. Both primary and continuous cell culture systems provide an in vitro alternative for quantitative evaluation of the toxicity of snake venoms. Crude Crotalus vegrandis venom was fractionated by molecular exclusion chromatography. The toxicity of C. vegrandis crude venom, hemorrhagic, and neurotoxic fractions were… CONTINUE READING

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